周怡波，理学博士，讲师，硕士生导师
邮箱：yibozhou@163.com
个人简介：
周怡波，理学博士，副教授，硕士生导师，（中国）股份有限公司官网“湖湘学者”特聘教授，细胞化学湖南省重点实验室副主任。2012年毕业于湖南大学物理化学专业，2012-2013年任职于中国航天科工集团。2017年毕业于湖南大学分析化学专业，2018年加入（中国）股份有限公司官网。目前主持承担国家自然科学基金青年项目、湖南省自然科学基金青年项目等课题。在Angew. Chem. Int. Ed.、 Anal. Chem.、Chem-Eur J等期刊发表论文多篇。
主要研究方向：
1. 有机聚合物材料的制备及生物应用
2. 荧光信号放大探针的设计及生物传感
主持或参加科研项目：
1. 长沙市自然科学基金, kq2208216, ATP多价结合驱动信号放大策略的构建及肝硬化成像分析, 2023/01-2024/12, 在研, 主持。
2. 化学生物传感与计量学国家重点实验室开放课题, 2021018, 基于H-聚集的零背景荧光信号放大纳米探针的构建及胚胎多硫化氢成像研究, 2022/04-2024/04, 在研, 主持。
3. 国家自然科学基金青年基金项目，21804012，胞浆蛋白辅助荧光放大”高灵敏检测及荧光成像成纤维细胞活化蛋白，2019/01-2021/12，已结题，主持。
4. 湖南省自然科学基金青年基金项目，2019JJ50634，金属离子辅助荧光放大纳米探针构建及其在炎症性肠病成像中的应用，2019/01-2022/12，已结题，主持。
5. 国家自然科学基金重点基金项目，21735001，生物体系自助式原位荧光信号放大瓶的创建及生化应用，2018/01-2022/12，在研，参与。
6. （中国）股份有限公司官网科研启动项目，在研，主持。
代表性论文：
(1) Yibo Zhou, Xiaofei Ma, Shan Hu, Sheng Yang, Jingru Guo, Junbin Li, Yue-Fei Zhang, Juewen Liu, Zhihe Qing*, and Ronghua Yang.* Rigidity-Dependent Emission: Inspired Selection of an ATP-Specific Polyvalent Hydrogen Binding-Lighted Fluorophore for Intracellular Amplified Imaging, Analytical Chemistry, 2023, org/10.1021/acs.analchem.3c00759. (SCI 1区)
(2) Taoyun Wang, Xu Huang, Sheng Yang, Shan Hu, Xianglan Zheng, Guojiang Mao, Yi Li*, Yibo Zhou.* Monitoring H2S fluctuation during autophagic fusion of lysosomes and mitochondria using a lysosome-targeting fluorogenic probe, Analytica Chimica Acta, 2023, 1265, 341356. (SCI 1区)
(3) Huihong Liu, Xianqing Zeng, Honghui Yin, Jing Chen, Wenzhi Xie, Guoqiang Zhou, Guojiang Mao, Yibo Zhou,* Sheng Yang.* A pH-switchable azo-based fluorescence reporter for lysosome-confined visualization of hypoxia status. Sensors & Actuators: B. Chemical., 2023, 381, 133431. (SCI 1区)
(4) Yibo Zhou, Zhengxuan Gu, Changhui Liu, Sheng Yang,* Xiaofei Ma, Qiaoshu Chen, Yanli Lei, Ke Quan, Juewen Liu, Zhihe Qing,* Ronghua Yang.* A Polymeric Nanobeacon for Revealing Hydrogen Polysulfides Fluctuation during Fertilization and Embryonic Development. Angew. Chem. Int. Ed., 2022, 61, e202114504. (SCI 1区)
(5) Yibo Zhou,* Hao Dong, Zhengxuan Gu, Sheng Yang, Minzhi Ouyang, Zhihe Qing, Xiaofei Ma, Shan Hu, JunBin Li, and Ronghua Yang.* Self-Immolative Dye-Doped Polymeric Probe for Precisely Imaging Hydroxyl Radicals by Avoiding Leakage. Analytical Chemistry, 2021, 93, 8, 12944−12953. (SCI 1区)
(6) Yibo Zhou, Keyi Yin, Hao Dong, Sheng Yang,* JunBin Li, Jinqiu Luo, Yi Li, and Ronghua Yang.* Long-Lasting Bioluminescence Imaging of the Fibroblast Activation Protein by an Amphiphilic Block Copolymer-Based Probe. Analytical Chemistry, 2021, 93, 8, 3726-3732. (SCI 1区)
(7) Yibo Zhou, Sheng Yang,* Jingru Guo, Hao Dong, Keyi Yin, Wei Tao Huang, and Ronghua Yang.* In Vivo Imaging of Hypoxia Associated with Inflammatory Bowel Disease by a Cytoplasmic Protein-Powered Fluorescence Cascade Amplifier. Analytical Chemistry, 2020, 92, 5787-5794. (SCI 1区)
(8) Yibo Zhou, Sheng Yang,* Yue Xiao, Zhen Zou, Zhihe Qing, Juewen Liu, and Ronghua Yang.* Cytoplasmic Protein-Powered In Situ Fluorescence Amplification for Intracellular Assay of Low-Abundance Analyte. Analytical Chemistry, 2019, 91, 15179-15186. (SCI 1区)
(9) Yibo Zhou, Xiufang Zhang, Sheng Yang,* Yuan Li, Zhihe Qing, Jing Zheng, Jishan Li, Ronghua Yang.* Ratiometric Visualization of NO/H2S Cross-Talk in Living Cells and Tissues Using a Nitroxyl-Responsive Two-Photon Fluorescence Probe, Analytical Chemistry, 2017, 89, 4587-4594. (SCI 1区)
(10) Yibo Zhou, Biwu Liu, Ronghua Yang, Juewen Liu.* Filling in the Gaps between Nanozymes and Enzymes: Challenges and Opportunities. Bioconjugate Chemistry, 2017, 28, 2903-2909. (ESI高被引)
(11) Yibo Zhou, Zhicheng Huang, Ronghua Yang, Juewen Liu.* Selection and Screening of DNA Aptamers for Inorganic Nanomaterials, Chemistry – A European Journal, 2018, 24, 2525-2532. (TOP期刊，SCI 2区)
(12) Yibo Zhou, Gang Yu,* Fangfang Chang, Bonian Hu, Chuan-Jian Zhong.* Gold-platinum alloy nanowires as highly sensitive materials for electrochemical detection of hydrogen peroxide, Analytica Chimica Acta, 2012, 757, 56-62. (SCI 2区)
研究生招生
本课题组开展生化传感相关领域基础和应用研究，优秀毕业生可推荐到知名大学或研究所攻读博士学位。欢迎具有生物、化学、化工等背景的有志同学报考研究生！
